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1

Design, synthesis, and biological evaluation of LNA nucleosides as adenosine A3 receptor ligands

Jacob Ravn, Katrine Qvortrup, Christoph Rosenbohm, Troels Koch

Journal:

Bioorganic & Medicinal Chemistry

Year:

2007

Language:

english

File:

PDF, 214 KB

english, 2007

2

Preparation of LNA Phosphoramidites

Pedersen, Daniel Sejer, Rosenbohm, Christoph, Koch, Troels

Journal:

Year:

2002

Language:

english

File:

PDF, 100 KB

english, 2002

3

LNA Antisense: A Review

Journal:

Current Physical Chemistry

Year:

2013

Language:

english

File:

PDF, 558 KB

english, 2013

4

On the in vitro and in vivo Properties of Four Locked Nucleic Acid Nucleotides Incorporated into an Anti-H-Ras Antisense Oligonucleotide

Kees Fluiter, Miriam Frieden, Jeroen Vreijling, Christoph Rosenbohm, Marit B. De Wissel, Signe M. Christensen, Troels Koch, Henrik Ørum, Frank Baas

Journal:

Year:

2005

Language:

english

File:

PDF, 406 KB

english, 2005

5

ChemInform Abstract: Preparation of LNA Phosphoramidites.

Daniel Sejer Pedersen, Christoph Rosenbohm, Troels Koch

Journal:

Year:

2002

File:

PDF, 28 KB

2002

6

Synthesis and Antiviral Evaluation of Novel Conformationally Locked Nucleosides and Masked 5′-Phosphate Derivatives Thereof.

Torsten Bryld, Marianne H. Soerensen, Poul Nielsen, Troels Koch, Claus Nielsen, Jesper Wengel

Journal:

Year:

2002

File:

PDF, 29 KB

2002

7

Nuclease Stability of LNA Oligonucleotides and LNA-DNA Chimeras

Miriam Frieden, Henrik F. Hansen, Troels Koch

Journal:

Year:

2004

File:

PDF, 52 KB

2004

8

Improved Synthesis of 2′-Amino-LNA

Signe M. Christensen, Christoph Rosenbohm, Mads Soerensen, Lotte-Emilie Larsen, Jesper Wengel, Troels Koch

Journal:

Year:

2004

File:

PDF, 52 KB

2004

9

New Standards in LNA Synthesis

Henrik F. Hansen, Otto Olsen, Troels Koch

Journal:

Year:

2004

File:

PDF, 53 KB

2004

10

Analogues of LNA (Locked Nucleic Acid): Synthesis of the 2′-Thio-LNA Ribothymidine and 5-Methylcytidine Phosphoramidites.

Daniel Sejer Pedersen, Troels Koch

Journal:

Year:

2004

File:

PDF, 49 KB

2004

11

PNA Synthesis by Boc Chemistry

Journal:

Year:

2005

File:

PDF, 8 KB

2005

12

Chemistry of Locked Nucleic Acids (LNA): Design, Synthesis, and Biophysical Properties

Jesper Wengel, Michael Petersen, Miriam Frieden, Troels Koch

Journal:

Year:

2005

File:

PDF, 8 KB

2005

13

PNA-peptide chimerae

Troels Koch, Michael Naesby, Pernilla Wittung, Mikkel Jørgensen, Charlotte Larsson, Ole Buchardt, Christopher J. Stanley, Bengt Nordén, Peter E. Nielsen, Henrik Ørum

Journal:

Tetrahedron Letters

Year:

1995

Language:

english

File:

PDF, 196 KB

english, 1995

14

LNA guanine and 2,6-diaminopurine. Synthesis, characterization and hybridization properties of LNA 2,6-diaminopurine containing oligonucleotides

Christoph Rosenbohm, Daniel Sejer Pedersen, Miriam Frieden, Flemming R. Jensen, Susan Arent, Sine Larsen, Troels Koch

Journal:

Bioorganic & Medicinal Chemistry

Year:

2004

Language:

english

File:

PDF, 380 KB

english, 2004

15

Solid-Phase synthesis of peptide nucleic acids

Dr. Leif Christensen, Richard Fitzpatrick, Brian Gildea, Kenneth H. Petersen, Henrik F. Hansen, Troels Koch, Michael Egholm, Ole Buchardt, Peter E. Nielsen, Dr. James Coull, Rolf H. Berg

Journal:

Journal of Peptide Science

Year:

1995

Language:

english

File:

PDF, 638 KB

english, 1995

16

PNA synthesis using a novel Boc/acyl protecting group strategy

Thomas Kofoed, Henrik F. Hansen, Henrik Ørum, Troels Koch

Journal:

Journal of Peptide Science

Year:

2001

Language:

english

File:

PDF, 185 KB

english, 2001

17

Chemistry of locked nucleic acids (LNA): Design, synthesis, and bio-physical properties

Jesper Wengel, Michael Petersen, Miriam Frieden, Troels Koch

Journal:

International Journal of Peptide Research and Therapeutics

Year:

2003

Language:

english

File:

PDF, 1.45 MB

english, 2003

18

Chemistry of locked nucleic acids (LNA): Design, synthesis, and bio-physical properties

Jesper Wengel, Michael Petersen, Miriam Frieden, Troels Koch

Journal:

International Journal of Peptide Research and Therapeutics

Year:

2005

Language:

english

File:

PDF, 476 KB

english, 2005

19

Improvements in automated PNA synthesis using Boc/Z monomers

TROELS KOCH, HENRIK F. HANSEN, PETER ANDERSEN, TINNA LARSEN, HANS G. BATZ, KENNETH OTTESON, HENRIK ØRUM

Journal:

Chemical Biology & Drug Design

Year:

1997

Language:

english

File:

PDF, 715 KB

english, 1997

20

PHOTOCLEAVAGE OF DNA: IRRADIATION OF QUINONE-CONTAINING REAGENTS CONVERTS SUPERCOILED TO LINEAR DNA

Troels Koch, J. Dezz Ropp, Stephen G. Sligar, Gary B. Schuster

Journal:

Photochemistry and Photobiology

Year:

1993

Language:

english

File:

PDF, 671 KB

english, 1993

21

Synthesis of 2â²-amino-LNA: a new strategyElectronic supplementary information (ESI) available: further experimental details and the structure of compound S11 (.pdb file). See http://www.rsc.org/suppdata/ob/b2/b208864a/

Rosenbohm, Christoph, Christensen, Signe M., SÃ¸rensen, Mads D., Pedersen, Daniel Sejer, Larsen, Lotte-Emilie, Wengel, Jesper, Koch, Troels

Journal:

Organic & Biomolecular Chemistry

Year:

2003

Language:

english

File:

PDF, 203 KB

english, 2003

22

Synthesis and Biological Evaluation of LNA Phosphoramidates

Jensen, Jacob, Sjøgren, Gitte, Hansen, Jens Bo, Rosenbohm, Christoph, Koch, Troels

Journal:

Nucleosides Nucleotides & Nucleic Acids

Year:

2008

Language:

english

File:

PDF, 158 KB

english, 2008

23

Chemistry of locked nucleic acids (LNA): Design, synthesis, and bio-physical properties

Jesper Wengel, Michael Petersen, Miriam Frieden, Troels Koch

Journal:

International Journal of Peptide Research and Therapeutics

Year:

2003

Language:

english

File:

PDF, 473 KB

english, 2003

24

Molar-Scale Synthesis of 1,2:5,6-Di- O -isopropylidene-α- d -allofuranose: DMSO Oxidation of 1,2:5,6-Di- O -isopropylidene-α- d -glucofuranose and Subsequent Sodium Borohydride Reduction

Christensen, Signe M., Hansen, Henrik F., Koch, Troels

Journal:

Organic Process Research & Development

Year:

2004

Language:

english

File:

PDF, 126 KB

english, 2004

25

The oxidative cleavability of protein cross-linking reagents containing organoselenium bridges

Koch, Troels, Suenson, Elisabeth, Henriksen, Ulla, Buchardt, Ole

Journal:

Bioconjugate Chemistry

Year:

1990

Language:

english

File:

PDF, 1.44 MB

english, 1990

26

Photochemical Immobilization of Anthraquinone Conjugated Oligonucleotides and PCR Amplicons on Solid Surfaces

Koch, Troels, Jacobsen, Nana, Fensholdt, Jef, Boas, Ulrich, Fenger, Mogens, Jakobsen, Mogens H.

Journal:

Bioconjugate Chemistry

Year:

2000

Language:

english

File:

PDF, 330 KB

english, 2000

27

Hepatotoxic Potential of Therapeutic Oligonucleotides Can Be Predicted from Their Sequence and Modification Pattern

Hagedorn, Peter H., Yakimov, Victor, Ottosen, Søren, Kammler, Susanne, Nielsen, Niels F., Høg, Anja M., Hedtjärn, Maj, Meldgaard, Michael, Møller, Marianne R., Ørum, Henrik, Koch, Troels, Lindow, Mort

Journal:

Nucleic Acid Therapeutics (Formerly Oligonucleotides)

Year:

2013

Language:

english

File:

PDF, 706 KB

english, 2013

28

Peptide Nucleic Acid-DNA Duplexes: Long Range Hole Migration from an Internally Linked Anthraquinone

Bruce Armitage, Danith Ly, Troels Koch, Henrik Frydenlund, Henrik Orum, Hans G. Batz and Gary B. Schuster

Journal:

Proceedings of the National Academy of Sciences

Year:

1997

Language:

english

File:

PDF, 1.36 MB

english, 1997

29

Enzymatic Reaction with Unnatural Substrates: DNA Photolyase (Escherichia coli) Recognizes and Reverses Thymine [2+2] Dimers in the DNA Strand of a DNA/PNA Hybrid Duplex

Danaboyina Ramaiah, Yongzhi Kan, Troels Koch, Henrik Orum and Gary B. Schuster

Journal:

Proceedings of the National Academy of Sciences

Year:

1998

Language:

english

File:

PDF, 1.05 MB

english, 1998

30

Hairpin-Forming Peptide Nucleic Acid Oligomers †

Armitage, Bruce, Ly, Danith, Koch, Troels, Frydenlund, Henrik, Ørum, Henrik, Schuster, Gary B.

Journal:

Year:

1998

Language:

english

File:

PDF, 231 KB

english, 1998

31

Photolytic cleavage of DNA by nitrobenzamido ligands linked to 9-aminoacridines gives DNA polymerase substrates in a wavelength-dependent reaction

Nielsen, Peter E., Egholm, Michael, Koch, Troels, Christensen, Joern B., Buchardt, Ole

Journal:

Bioconjugate Chemistry

Year:

1991

Language:

english

File:

PDF, 2.53 MB

english, 1991

32

Effect of LNA Modifications on Small Molecule Binding to Nucleic Acids

Marin, Violeta, Hansen, Henrik F., Koch, Troels, Armitage, Bruce A.

Journal:

Journal of Biomolecular Structure and Dynamics

Year:

2004

Language:

english

File:

PDF, 394 KB

english, 2004

33

Nuclease Stability of LNA Oligonucleotides and LNA-DNA Chimeras

Frieden, Miriam, Hansen, Henrik F., Koch, Troels

Journal:

Nucleosides Nucleotides & Nucleic Acids

Year:

2003

Language:

english

File:

PDF, 186 KB

english, 2003

34

PNA∗Synthesis and Diagnostic Application

Koch, Troels, Borre, Martin B., Naesby, Michael, Batz, Hans G., Ørum, Henrik

Journal:

Nucleosides and Nucleotides

Year:

1997

Language:

english

File:

PDF, 245 KB

english, 1997

35

Pitfalls in Characterization of Protein Interactions Using Radioiodinated Crosslinking Reagents. Preparation and Testing of a Novel Photochemical 125I-Label Transfer Reagent

Koch, Troels, Suenson, Elisabeth, Korsholm, Birgitte, Henriksen, Ulla, Buchardt, Ole

Journal:

Bioconjugate Chemistry

Year:

1994

Language:

english

File:

PDF, 1.94 MB

english, 1994

36

Synthesis and antiviral evaluation of novel conformationally locked nucleosides and masked 5′-phosphate derivatives thereof

Bryld, Torsten, Sørensen, Marianne H., Nielsen, Poul, Koch, Troels, Nielsen, Claus, Wengel, Jesper

Journal:

Journal of the Chemical Society Perkin Transactions 1

Year:

2002

Language:

english

File:

PDF, 176 KB

english, 2002

37

Quantum Mechanical Studies of DNA and LNA

Koch, Troels, Shim, Irene, Lindow, Morten, Ørum, Henrik, Bohr, Henrik G.

Journal:

Nucleic Acid Therapeutics (Formerly Oligonucleotides)

Year:

2014

Language:

english

File:

PDF, 716 KB

english, 2014

38

Synthesis of 2′-Amino-LNA Purine Nucleosides

Ravn, Jacob, Rosenbohm, Christoph, Christensen, Signe M., Koch, Troels

Journal:

Nucleosides Nucleotides & Nucleic Acids

Year:

2006

Language:

english

File:

PDF, 197 KB

english, 2006

39

Long Range Electron Transfer in PNA/DNA Duplexes

Koch, Troels, Armitage, Bruce, Hansen, Henrik F., Ørum, Henrik, Schuster, Gary B.

Journal:

Nucleosides and Nucleotides

Year:

1999

Language:

english

File:

PDF, 126 KB

english, 1999

40

Improved Synthesis of 2′-Amino-LNA

Christensen, Signe M., Rosenbohm, Christoph, Sørensen, Mads, Larsen, Lotte-Emilie, Wengel, Jesper, Koch, Troels

Journal:

Nucleosides Nucleotides & Nucleic Acids

Year:

2003

Language:

english

File:

PDF, 187 KB

english, 2003

41

New Standards in LNA Synthesis

Hansen, Henrik F., Olsen, Otto, Koch, Troels

Journal:

Nucleosides Nucleotides & Nucleic Acids

Year:

2003

Language:

english

File:

PDF, 182 KB

english, 2003

42

Evaluation of LNA-Modified DNAzymes Targeting a Single Nucleotide Polymorphism in the Large Subunit of RNA Polymerase II

Fluiter, Kees, Frieden, Miriam, Vreijling, Jeroen, Koch, Troels, Baas, Frank

Journal:

Oligonucleotides

Year:

2005

Language:

english

File:

PDF, 231 KB

english, 2005

43

Analogues of LNA (Locked Nucleic Acid): Synthesis of the 2′-Thio-LNA Ribothymidine and 5-Methylcytidine Phosphoramidites

Pedersen, Daniel Sejer, Koch, Troels

Journal:

Year:

2004

Language:

english

File:

PDF, 85 KB

english, 2004

44

PCSK9 LNA Antisense Oligonucleotides Induce Sustained Reduction of LDL Cholesterol in Nonhuman Primates

Lindholm, Marie W, Elmén, Joacim, Fisker, Niels, Hansen, Henrik F, Persson, Robert, Møller, Marianne R, Rosenbohm, Christoph, Ørum, Henrik, Straarup, Ellen M, Koch, Troels

Journal:

Molecular Therapy

Year:

2012

Language:

english

File:

PDF, 234 KB

english, 2012

45

Synthesis of L-(+)-Selenomethionine

Koch, Troels, Buchardt, Ole

Journal:

Year:

1993

File:

PDF, 229 KB

1993

46

Analysis of a seventeenth-century panel painting by reflection terahertz time-domain imaging (THz-TDI): contribution of ultrafast optics to museum collections inspection

Koch Dandolo, Corinna L., Filtenborg, Troels, Skou-Hansen, Jacob, Jepsen, Peter Uhd

Journal:

Applied Physics A: Materials Science & Processing

Year:

2015

Language:

english

File:

PDF, 1.94 MB

english, 2015

47

Protein Kinase C-α is a Critical Protein for Antisense Oligonucleotide-Mediated Silencing in Mammalian Cells

Castanotto, Daniela, Lin, Min, Kowolik, Claudia, Koch, Troels, Hansen, Bo Rode, Oerum, Henrik, Stein, C A

Journal:

Molecular Therapy

Year:

2016

Language:

english

File:

PDF, 2.75 MB

english, 2016

48

Stopped-flow kinetics of locked nucleic acid (LNA)–oligonucleotide duplex formation: studies of LNA–DNA and DNA–DNA interactions

CHRISTENSEN, Ulla, JACOBSEN, Nana, RAJWANSHI, Vivek K., WENGEL, Jesper, KOCH, Troels

Journal:

Biochemical Journal

Year:

2001

Language:

english

File:

PDF, 132 KB

english, 2001

49

Stopped-flow kinetics of locked nucleic acid (LNA)‒oligonucleotide duplex formation: studies of LNA‒DNA and DNA‒DNA interactions

CHRISTENSEN, Ulla, JACOBSEN, Nana, RAJWANSHI, Vivek K., WENGEL, Jesper, KOCH, Troels

Journal:

Biochemical Journal

Year:

2001

Language:

english

File:

PDF, 132 KB

english, 2001

50

Erythema nodosum and the risk of tuberculosis in a high incidence setting

Bjorn-Mortensen, Karen, Ladefoged, Karin, Simonsen, Jacob, Michelsen, Sascha W., Sørensen, Hans Christian F., Koch, Anders, Lillebaek, Troels, Andersen, Aase Bengaard, Soborg, Bolette

Journal:

International Journal of Circumpolar Health

Year:

2016

Language:

english

File:

PDF, 695 KB

english, 2016